The effect of passive leg-raising maneuver on hemodynamic stability during anesthesia induction for adult cardiac surgery

Solmaz Fakhari, Eissa Bilehjani, Haleh Farzin, Hojjat Pourfathi, Mohsen Chalabianlou Cardiovascular Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Introduction: Some cardiac patients do not tolerate the intravenous fluid load commonly administered before anesthesia induction.This study investigated preindu

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In silico predictive model to determine vector-mediated transport properties for the blood–brain barrier choline transporter

Sergey Shityakov, Carola Förster Department of Anaesthesia and Critical Care, University of Würzburg, Würzburg, Germany Abstract: The blood–brain barrier choline transporter (BBB-ChT) may have utility as a drug delivery vector to the central nervous system (CNS).We therefore initiated molecular docking studies with the AutoDock

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Harnessing adenovirus in cancer immunotherapy: evoking cellular immunity and targeting delivery in cell-specific manner

Abstract Recombinant adenovirus (rAd) regimens, including replication-competent oncolytic adenovirus (OAV) and replication-deficient adenovirus, have been identified as potential cancer therapeutics.OAV presents advantages such as selective replication, oncolytic efficacy, and tumor microenvironment (TME) remodeling.In click here this perspective,

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